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We offer Learn to Swim programs and a full Sports Fitness center in the capital region and in NYC –  Long Island region we offer our sought offer learn to swim program. Select the location closest to you for further details of what each region can offer you and your family. We look forward to seeing you.

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Cohoes, NY

Providing the capital and surrounding areas, with a full-fledged Sports Complex. Whether you want to work out, play sports or do some laps in our pool. We have you covered and look forward to seeing you and your family.

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Serving NYC, Queens, Douglaston, Flushing, Richmond Hill, Brooklyn, Long Island and surrounding areas with our sought after aquatics programs.  Enter our facilities in order to know more about what we offer in the NYC-Long Island regions. We look forwards to seeing you soon.

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Gateway Sports & Pools Inc. is a nonprofit organization that believes in creating and nurturing, stable and culturally diverse family enviroment where our youth can reach their full potential.

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ABC Transporters in Neurological Disorders: An Important Gateway for Botanical Compounds Mediated Neuro-Therapeutics

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Review

. 2019;19(10):795-811.

doi: 10.2174/1568026619666190412121811.

Niraj Kumar Jha 
¹
, Rohan Kar 
¹
, Rituraj Niranjan 
²

Affiliations

Affiliations

• ¹ Department of Biotechnology, Noida Institute of Engineering & Technology (NIET), Greater Noida, India.
• ² Unit of Microbiology and Molecular Biology, ICMR-Vector Control Research Center, Puducherry-605006, India.

• PMID:

  30977450

• DOI:

  10. 2174/1568026619666190412121811

Review

Niraj Kumar Jha et al.

Curr Top Med Chem.

2019.

. 2019;19(10):795-811.

doi: 10.2174/1568026619666190412121811.

Authors

Niraj Kumar Jha 
¹
, Rohan Kar 
¹
, Rituraj Niranjan 
²

Affiliations

• ¹ Department of Biotechnology, Noida Institute of Engineering & Technology (NIET), Greater Noida, India.
• ² Unit of Microbiology and Molecular Biology, ICMR-Vector Control Research Center, Puducherry-605006, India.

• PMID:

  30977450

• DOI:

  10.2174/1568026619666190412121811

Abstract

Neurodegeneration is a distinguishing feature of many age related disorders and other vector borne neuroinflammatory diseases. There are a number of factors that can modulate the pathology of these disorders. ATP-binding cassette (ABC) transporters are primarily involved in the maintenance of normal brain homeostasis by eliminating toxic peptides and compounds from the brain. Also, ABC transporters protect the brain from the unwanted effects of endogenous and exogenous toxins that can enter the brain parenchyma. Therefore, these transporters have the ability to determine the pathological outcomes of several neurological disorders. For instance, ABC transporters like P-glycoprotein (ABCB1), and BCRP (ABCG2) have been reported to facilitate the clearance of peptides such as amyloid-β (Aβ) that accumulate in the brain during Alzheimer’s disease (AD) progression. Other members such as ABCA1, ABCA2, ABCC8, ABCC9, ABCG1 and ABCG4 also have been reported to be involved in the progression of various brain disorders such as HIV-associated dementia, Multiple sclerosis (MS), Ischemic stroke, Japanese encephalitis (JE) and Epilepsy. However, these defective transporters can be targeted by numerous botanical compounds such as Verapamil, Berberine and Fascalpsyn as a therapeutic target to treat these neurological outcomes. These compounds are already reported to modulate ABC transporter activity in the CNS. Nonetheless, the exact mechanisms involving the ABC transporters role in normal brain functioning, their role in neuronal dysfunction and how these botanical compounds ensure and facilitate their therapeutic action in association with defective transporters still remain elusive. This review therefore, summarizes the role of ABC transporters in neurological disorders, with a special emphasis on its role in AD brains. The prospect of using botanical/natural compounds as modulators of ABC transporters in neurological disorders is discussed in the latter half of the article.

Keywords:

ABC transporter; Alzheimer’s disease; Botanical compounds; Neurodegeneration; Neuroinflammation; Neurotherapeutics..

Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

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New-AzApplicationGatewayFirewallPolicyExclusion (Az.Network) | Microsoft Learn

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Module:

Az. Network

Throws a firewall policy exception

Syntax
-MatchVariable

-SelectorMatchOperator
-Selector
[-ExclusionManagedRuleSet ]
[-DefaultProfile ]
[]

Description

Cmdlet New-AzApplicationGatewayFirewallPolicyExclusion new list of firewall policy exclusion rules. This command creates a new exception entry for the RequestHeaderNames variable and an operator named StartsWith and a Selector named xyz. The exception entry is stored in $exclusionEntry.

Example 2

 $exclusionEntry = New-AzApplicationGatewayFirewallPolicyExclusion -MatchVariable "RequestHeaderKeys" -SelectorMatchOperator "Contains" -Selector "abc" 

This command creates a new exception entry for the RequestHeaderKeys variable and the Contains and Select operator or named abc. The exception entry is stored in $exclusionEntry.

Example 3

 $exclusionEntry = New-AzApplicationGatewayFirewallPolicyExclusion -MatchVariable "RequestHeaderNames" -SelectorMatchOperator "StartsWith" -Selector "xyz" -ExclusionManagedRuleSet $exclusionManagedRuleSet 

This command creates a new exception entry for the RequestHeaderNames variable and an operator named StartsWith, a Selector named xyz, and an ExclusionManagedRuleSet named $exclusionManagedRuleSet. The exception entry is stored in $exclusionEntry. Input Data

None

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PSApplicationGatewayFirewallPolicyExclusion

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DVP10XU – Internet video transmission gateway – Gateways

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